- Facile synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides.
Facile synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides.
Journal of peptide science : an official publication of the European Peptide Society (2005-10-26)
Nanyan Fu, Qihan Zhang, Lifang Duan, Jiaxi Xu
PMID16245363
ABSTRACT
A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehydes, and methyl dichlorophosphite, followed by aminolysis with amino acid esters or alcoholysis with hydroxy esters.
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