- An efficient approach to the asymmetric total synthesis of (-)-anisodine.
An efficient approach to the asymmetric total synthesis of (-)-anisodine.
European journal of medicinal chemistry (2006-01-18)
Junbiao Chang, Weilin Xie, Limin Wang, Nianchun Ma, Senxiang Cheng, Jingxi Xie
PMID16414152
ABSTRACT
-Anisodine (l-6,7-epoxy-3-tropyl-alpha-hydroxytropate), which was isolated from the medicinal plant Scopolia tanguticus Maxim, was the first efficiently prepared using 6-beta-acetyltropine as the starting material via a key step of the Sharpless asymmetric dihydroxylation (AD). The intermediate compounds 10 and 11 showed promising cholinergic activity.
MATERIALS