- Total synthesis of (-)-quinocarcin by gold(I)-catalyzed regioselective hydroamination.
Total synthesis of (-)-quinocarcin by gold(I)-catalyzed regioselective hydroamination.
Angewandte Chemie (International ed. in English) (2012-08-15)
Hiroaki Chiba, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno
PMID22890756
ABSTRACT
In control: The novel and enantioselective total synthesis of (-)-quinocarcin includes the highly stereoselective preparation of the 2,5-cis-pyrrolidine by intramolecular amination, a selective substrate-controlled 6-endo-dig intramolecular alkyne hydroamination with a cationic Au(I) catalyst, and Lewis-acid-mediated ring-opening/halogenation sequence.