SRP6595

IL-22 human

recombinant, expressed in HEK 293 cells (Ala 34 - Ile 179), ≥95% (SDS-PAGE)

• Synonym(s): IL-TIF, ZCYTO18
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in HEK 293 cells (Ala 34 - Ile 179)
• tag: His tagged
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized powder
• mol wt: calculated mol wt 17.6 kDa (a polyhistidine tag at the N-terminus.); observed mol wt 21-33 kDa (DTT-reduced protein.Protein migrates as 21-33 kDa in a SDS-PAGE due to glycosylation.; )
• packaging: pkg of 10 μg
• impurities: <1 EU/μg (LAL test)
• UniProt accession no.: Q9GZX6
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... IL22(50616)

Description

General description

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable