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R1033

Sigma-Aldrich

RN-1747

≥98% (HPLC)

Synonym(s):

1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine;, 1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine

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About This Item

Empirical Formula (Hill Notation):
C17H18ClN3O4S
CAS Number:
1024448-59-6
Molecular Weight:
395.86
MDL number:
MFCD04154169
UNSPSC Code:
51111800
PubChem Substance ID:
329823995
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

light yellow to light tan

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1cc(Cl)ccc1S(=O)(=O)N2CCN(CC2)Cc3ccccc3

InChI

1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2

InChI key

ZNLVYSJQUMALEO-UHFFFAOYSA-N

Biochem/physiol Actions

TRPV4, a close relative of the vanilloid receptor TRPV1, is activated by diverse modalities such as endogenous lipid ligands, hypotonicity, protein kinases and, possibly, mechanical inputs. TRPV4 is a nociceptor playing an important role in inflammatory and neuropathic mechanical hyperalgesia in rodent models apparently specifically activated under pathological conditions.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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