850081P

Monolyso Heart CA

Avanti Polar Lipids 850081P, powder

• Synonym(s): monolysocardiolipin (Heart, Bovine) (sodium salt)
• CAS Number: 383907-65-1
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 10 mg (850081P-10mg)
• manufacturer/tradename: Avanti Polar Lipids 850081P
• lipid type: phosphoglycerides
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O=P([O-])(OC[C@]([H])(O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O.[Na+].[Na+]

Description

General description

Monolysocardiolipin (MLCL) is a class of phospholipid related to cardiolipin. MLCL is a triacylated phospholipid, uncommon in bacterial or eukaryotic membranes. MLCL is prepared from cardiolipin by the hydrolysis action of phospholipase A2 (PLA2).

Application

Monolyso Heart CA is suitable for use:

• as substrate for the synthesis of cardiolipin by the enzyme acyl-CoA:lysocardiolipin acyltransferase (ACLAT1)
• as substrate for the assay of mitochondrial monolysocardiolipin acyltransferase (MLCL AT) activity
• in the preparation of affinity resin MLCL-adriamycin-agarose for the purification of MLCL AT

Biochem/physiol Actions

Monolysocardiolipin (MLCL) is a substrate for the biosynthesis of cardiolipin in heart by the activity of MLCL acyltransferase. MLCL is a marker for Barth syndrome. MLCL is implicated in apoptosis.

Packaging

5 mL Clear Glass Sealed Ampule (850081P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3