NCSTN
nicastrin
Synonyms:
APH2
Species:
Human NCSTN (23385), Mouse Ncstn (59287), Rat Ncstn (289231), Zebrafish ncstn (494449), cow NCSTN (514929), Horse NCSTN (100058515), domestic cat NCSTN (101090586), dog NCSTN (488638), chicken NCSTN (426905), domestic guinea pig Ncstn (100731821) ...More
UniProtKB ID:
Gene ID:
- Human(23385) Summary: This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(59287) nicastrin
- Rat(289231) nicastrin
- Zebrafish(494449) nicastrin
- cow(514929) nicastrin
- Horse(100058515) nicastrin
- domestic cat(101090586) nicastrin
- dog(488638) nicastrin
- chicken(426905) nicastrin
- domestic guinea pig(100731821) nicastrin
- naked mole-rat(101718052) nicastrin
- sheep(101120457) nicastrin
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Nicastrin (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Nicastrin (ab1) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-NCSTN antibody produced in mouse, clone 1E8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-NCSTN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-NCSTN antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
