C2
complement component 2
Synonyms:
CO2
Species:
Human C2 (717), Mouse C2 (12263), Rat C2 (24231), naked mole-rat C2 (101723809), domestic guinea pig C2 (100716184), sheep C2 (101115321), Domestic Rabbit C2 (100355553), chicken C2 (419574), cow C2 (515440), Horse C2 (100059162) ...More
UniProtKB ID:
Gene ID:
- Human(717) Summary: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
- Mouse(12263) complement component 2 (within H-2S)
- Rat(24231) complement component 2
- naked mole-rat(101723809) complement component 2
- domestic guinea pig(100716184) complement component 2
- sheep(101115321) complement component 2
- Domestic Rabbit(100355553) complement component 2
- chicken(419574) complement component 2
- cow(515440) complement component 2
- Horse(100059162) complement component 2
- domestic cat(101092434) complement component 2
- dog(474853) complement component 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-C2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-C2 (AB2) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
dog, horse, human, mouse, pig, rat
Application
western blot
Proteins
Product Number
Description
Species