- Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
Bioorganic & medicinal chemistry letters (2012-05-09)
Tiansheng Wang, Leonard Duncan, Wenxin Gu, Hardwin O'Dowd, Yunyi Wei, Emanuele Perola, Jonathan Parsons, Christian H Gross, Cameron Stuver Moody, S J Ryan Arends, Paul S Charifson
PMID22560470
摘要
A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD(+)-dependent DNA ligase that possess potency against Gram-positive bacteria.
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