品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
light yellow to dark yellow
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O
InChI
1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)
InChI 密鑰
WCEDGRTWDSHZHF-UHFFFAOYSA-N
生化／生理作用
KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells
Lee Y, et al.
Oncotarget, 8(25), 41091-41091 (2017)
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