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Merck
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文件

SML1489

Sigma-Aldrich

FICZ

≥95% (HPLC), lyophilized powder, AhR agonist

别名:

5,11-二氢-吲哚[3,2-b] 咔唑-6-甲醛, 6-甲酰吲哚[3,2-b] 咔唑

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About This Item

经验公式（希尔记法）:
C19H12N2O
CAS号:
172922-91-7
分子量:
284.31
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

FICZ, ≥95% (HPLC)

品質等級

100

化驗

≥95% (HPLC)

形狀

lyophilized powder

顏色

yellow

溶解度

DMSO: 0.5 mg/mL, clear (warmed)

儲存溫度

−20°C

生化／生理作用

FICZ 是芳香烃受体 (aryl hydrocarbon receptor,AhR) 的强效高亲和力配体，是一种配体激活的转录因子，可激活 CYP1A1 基因等芳香烃代谢酶基因的表达，也被证明在细胞周期调控、许多组织的发育成熟、控制炎症和免疫反应中具有多种额外的作用。FICZ 是色氨酸的光产物，被认为是内源性 AhR 配体。其效力极强，Kd 值为 0.07 nM。
FICZ（6-甲酰吲哚 (3,2b) 咔唑）是色氨酸的光氧化产物，可能作为光的化学信使。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.
Denison M S and Nagy S R
Annual Review of Pharmacology, 43(1), 309-334 (2003)
Sibei Tao et al.
Journal of cellular and molecular medicine, 25(2), 1035-1047 (2020-12-07)
Acute kidney injury (AKI) is a multifactorial disease of various aetiologies. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that responds to ligands to induce or repress gene expressions, thereby regulating a diverse spectrum of biological or pathophysiologic effects.
Yann Malaisé et al.
Toxicology in vitro : an international journal published in association with BIBRA, 69, 104993-104993 (2020-09-11)
The endocrine disruptor and food contaminant bisphenol A (BPA) is frequently present in consumer plastics and can produce several adverse health effects participating in the development of inflammatory and autoimmune diseases. Regulatory restrictions have been established to prevent risks for
Hui Li et al.
FEBS letters, 593(9), 952-961 (2019-04-07)
Interleukin (IL)-17 plays a critical role in the pathogenesis of inflammation and autoimmune diseases. The aryl hydrocarbon receptor (AHR) is a transcription factor responsible for the elimination of xenobiotic chemicals. However, it remains unknown whether AHR is involved in IL-17
Barbora Vyhlídalová et al.
International journal of molecular sciences, 21(7) (2020-04-15)
We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed substantially, comprising
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