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Merck
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Key Documents

SCP0077

Sigma-Aldrich

Caspase 2 Substrate (ICH-1), chromogenic

≥90% (HPLC), lyophilized

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About This Item

经验公式(希尔记法):
C29H41N7O12
分子量:
679.68
分類程式碼代碼:
12352202
NACRES:
NA.32

product name

Caspase 2 Substrate (ICH-1), chromogenic, ≥90% (HPLC)

化驗

≥90% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥75%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Ac-Val-Asp-Val-Ala-Asp-pNA

應用

Caspase 2 is a cysteine protease that is potentially involved in cell cycle regulation and tumour suppression may be detected using peptides that contain the pentapeptide VDVAD such as the chromogenic and fluorogenic substrates: Ac-VDVAD-pNa (Acetyl-Val-Asp-Val-Ala-Asp-p- nitroanalide), chromogenic and MCA-VDVADGW-DNP-K-NH2, fluorogenic.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
Tang Y, Wells JA, Arkin MR.
The Journal of Biological Chemistry, 286, 31147-34154 (2011)
Tanja Kitevska et al.
Apoptosis : an international journal on programmed cell death, 14(7), 829-848 (2009-05-30)
The caspases are an evolutionarily conserved family of cysteine proteases, with essential roles in apoptosis or inflammation. Caspase-2 was the second caspase to be cloned and it resembles the prototypical nematode caspase CED-3 more closely than any other mammalian protein.

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