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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~95 kDa
物種活性
human
包裝
antibody small pack of 25 μL
濃度
~1.5 mg/mL
技術
western blot: 1.5-3.0 μg/mL using RAW264 cell extracts
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CYBB(1536)
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一般說明
CYBB (cytochrome b-245), belongs to the family of NADPH oxidases, that catalyze the generation of the superoxide ion. It is a six-transmembrane glycoprotein, that binds heme, flavin and NADPH. CYBB associates with membrane-bound p22phox to assemble the heavy subunit of flavocytochrome b558, the catalytic component of phagocyte NADPH oxidase. It also associates with four cytosolic components p47phox, p67phox, p40phox and Rac2 required for NADPH oxidase activity. Homologs of the NOX protein family include the catalytic subunits NOX1, NOX3-5, Duox1 and Duox2. NOX2/gp91phox is expressed in neutrophils and phagocytes.
應用
Anti-CYBB antibody produced in rabbit has been used in immunoblotting and western blotting.
生化／生理作用
CYBB (also known as cytochrome b-245) promotes neurotoxic activation of microglia, that play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). NOX1, NOX3-5, Duox1 and Duox2 plays important roles in redox-dependent cell signaling, inflammation and in neurodegenerative diseases. In ALS mice, deletion of either NOX1 or NOX2 gene has significantly slowed disease progression and improved survival.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy
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Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome
Lin KC, et al.
Mediators of Inflammation, 2018 (2018)
Perinatal alpha-tocopherol overload programs alterations in kidney development and renal angiotensin II signaling pathways at birth and at juvenile age: Mechanisms underlying the development of elevated blood pressure
Ribeiro VS, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(7), 2458-2471 (2018)
Cyril Chéret et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(46), 12039-12051 (2008-11-14)
Reactive oxygen species (ROS) modulate intracellular signaling but are also responsible for neuronal damage in pathological states. Microglia, the resident CNS macrophages, are prominent sources of ROS through expression of the phagocyte oxidase which catalytic subunit Nox2 generates superoxide ion
Juliane S Farias et al.
Archives of biochemistry and biophysics, 684, 108306-108306 (2020-02-23)
Maternal endotoxemia has been shown to increase renal collagen deposition in the offspring. Renal fibrosis is a hallmark of progressive chronic kidney disease. It was investigated whether maternal reactive oxygen species (ROS) leads to renal fibrosis or exacerbates unilateral ureteral
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