PZ0005

伏立康唑

≥98% (HPLC), powder, ergosterol synthesis inhibitor

• 别名: 2R，3S-2-（2,4-二氟苯基）-3-（5-氟嘧啶-4-基）-1-（1H-1,2,4-三唑-1-基）丁-2-醇, UK-109496
• 经验公式（希尔记法）: C₁₆H₁₄F₃N₅O
• CAS号: 137234-62-9
• 分子量: 349.31
• MDL號碼: MFCD00905717
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329823674
• NACRES: NA.77

属性

• product name: 伏立康唑, ≥98% (HPLC)
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white
• 溶解度: DMSO: >20 mg/mL
• 儲存溫度: room temp
• SMILES 字串: C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
• InChI: 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
• InChI 密鑰: BCEHBSKCWLPMDN-MGPLVRAMSA-N

说明

一般說明

Voriconazole is a triazole and a synthetic derivative of fluconazole.

應用

Voriconazole has been used:

• as a control and Erg11 inhibitor in YPD medium
• as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
• as an antifungal agent to test its interactions with valproic acid (VPA)
• to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

生化／生理作用

伏立康唑是用于治疗严重真菌感染的抗真菌药。伏立康唑通过抑制 CYP450 依赖性 14-α甾醇脱甲基酶来抑制麦角固醇合成，从而导致真菌细胞膜中的麦角固醇减少。

Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.

安全信息

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H301,H341,H351,H361,H371,H372,H373,H412
• 防範說明: P202 - P260 - P264 - P273 - P280 - P301 + P310
• 危險分類: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral
• 標靶器官: Eyes, Liver,Kidney
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable