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Merck

P9107

Sigma-Aldrich

Anti-Potassium Channel Kv1.3 (Charybdotoxin-Sensitive Voltage-Dependent Potassium Channel, HLK3) antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

IgG fraction of antiserum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

lyophilized powder

物種活性

rat, mouse, human

技術

immunocytochemistry: 1:50 using cells permeabilized with 0.2% Triton X-100
western blot (chemiluminescent): 1:100

UniProt登錄號

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)

特異性

Recognizes a full-length Kv1.3 protein. Does not cross-react with other potassium channel antigens.

免疫原

highly purified GST fusion protein from the C-terminal of human potassium channel Kv1.3. The protein corresponds to amino acids 471-523.

應用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

外觀

Lyophilized at ~1 mg/ml from phosphate buffered saline, pH 7.4, containing 5% sucrose, 1% bovine serum albumin, and 0.025% sodium azide.

準備報告

Protein A purified.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Y C Cai et al.
DNA and cell biology, 11(2), 163-172 (1992-03-01)
Voltage-gated potassium channels play important functional roles in the development and maintenance of human lymphocyte functions. One such channel, known as the type n channel, has been well defined in human T cells and exhibits unique functional properties that distinguish
B Attali et al.
The Journal of biological chemistry, 267(12), 8650-8657 (1992-04-25)
Low stringency screening of a Jurkat cDNA library with a rat brain K+ channel (RCK1) probe has resulted in the isolation of HLK3, a voltage-gated K+ channel. In Xenopus oocytes, the HLK3 clone directs the expression of a rapidly activating
Stella A Nicolaou et al.
Journal of immunology (Baltimore, Md. : 1950), 183(10), 6296-6302 (2009-10-21)
The immunological synapse (IS), a highly organized structure that forms at the point of contact between a T cell and an APC, is essential for the proper development of signaling events, including the Ca(2+) response. Kv1.3 channels control Ca(2+) homeostasis
Yi-Je Chen et al.
PloS one, 8(11), e81006-e81006 (2013-12-07)
Allograft vasculopathy (AV) remains one of the major challenges to the long-term functioning of solid organ transplants. Although its exact pathogenesis remains unclear, AV is characterized by both fibromuscular proliferation and infiltration of CD4(+) memory T cells. We here tested

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