P5057

Paromomycin sulfate salt 硫酸盐

powder, suitable for cell culture, BioReagent

• 经验公式（希尔记法）: C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• CAS号: 1263-89-4
• 分子量: 615.63 (free base basis)
• Beilstein: 5715182
• 分類程式碼代碼: 12352207
• PubChem物質ID: 24898585
• NACRES: NA.76

属性

• product name: Paromomycin sulfate salt 硫酸盐, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg
• 產品線: BioReagent
• 品質等級: 200
• 形狀: powder
• 效力: ≥675 μg per mg
• 技術: cell culture | mammalian: suitable
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: protein synthesis | interferes
• SMILES 字串: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• InChI 密鑰: OYJABWUHUYVDMJ-UDXJMMFXSA-N

说明

一般說明

Chemical structure: aminoglycoside

Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

應用

• Paromomycin sulfate salt has been used as a:
• reference compound in antileishmanial activity
• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.

Recommended for use in cell culture applications at 100mg/L.

Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

生化／生理作用

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

其他說明

1g,5g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable