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Merck

G5419

Sigma-Aldrich

单克隆抗-谷氨酸脱羧酶 67(GAD67) 小鼠抗

clone K-87, purified antibody

别名:

抗-GAD 67

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

K-87, monoclonal

分子量

antigen 67 kDa

物種活性

rat, mouse, human

濃度

~1 mg/mL

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:20,000 (with antigen-retrieval step)
western blot: 1:500-1:20,000 using mouse brain extract

同型

IgG1κ

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

目標翻譯後修改

unmodified

基因資訊

human ... GAD1(2571)
mouse ... Gad1(14415)
rat ... Gad1(24379)

一般說明

谷氨酸脱羧酶67(GAD67)由基因谷氨酸脱羧酶1(GAD1)编码。GAD1基因位于人染色体2q31.1。GAD67位于树突和细胞体。

特異性

与 GAD67 特异性反应。不与 GAD65 发生交叉反应。

免疫原

来自小鼠 GAD67 的合成肽(氨基酸 87-106)。
该肽与 GAD65 不具有同源性。

應用

小鼠抗谷氨酸脱羧酶67(GAD67)单克隆抗体已被用于:
  • 免疫组织荧光
  • 蛋白质印迹
  • 免疫组织化学

抗谷氨酸脱羧酶 67(GAD67)单克隆抗体适用于免疫印迹、免疫印迹(1:500-1:20,000 稀释,小鼠脑提取物)和免疫组化(1:500-1:20,000 稀释,小鼠脑切片)。

生化/生理作用

谷氨酸脱羧酶67(GAD67)涉及 γ-氨基丁酸 (GABA)的生产,氨基丁酸是中枢神经系统 (CNS)中的一种抑制性神经递质。GAD67缺乏会导致精神病、精神分裂和双向情感障碍。

外觀

在含有 0.01% 叠氮化钠的磷酸盐缓冲盐水中的溶液。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Major depressive disorder (MDD) is a recurring psychiatric illness that causes substantial health and socioeconomic burdens. Clinical reports have revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in individuals with MDD. Preclinical models suggest that

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