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About This Item
经验公式（希尔记法）:
C22H29N3O3S2 · xC2HF3O2
CAS号:
分子量:
447.61 (free base basis)
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77
品質等級
化驗
≥95% (HPLC)
形狀
film
儲存條件
desiccated
溶解度
H2O: ≥2 mg/mL
運輸包裝
dry ice
儲存溫度
−70°C
SMILES 字串
OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2
InChI
1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1
InChI 密鑰
GJEFFRDWFVSCOJ-PXPMWPIZSA-N
應用
法呢基转移酶抑制剂277（FTI-277）已被用于
- 在乳腺癌细胞系中抑制蛋白法呢基化。
- 骨髓分离的成人多系诱导细胞（MIAMI）中。
- 在与带有SV40基因细胞（COS-7）的起源中抑制CV-1中的法呢基转移酶。
生化／生理作用
法呢基转移酶抑制剂277（FTI-277）可介导多发性骨髓瘤的细胞凋亡，并被认为是一种潜在的治疗剂。
可拮抗H和K-Ras致癌信号的强效（pM/nM）Ras CAAX拟肽。 法呢基转移酶（Ftase）抑制剂IC50 = 50 nM。
包裝
极易吸湿材料，与脱氧的MeOH一起包装在干燥的房间中，并抽走溶剂。与干燥剂一起储存。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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