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化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: ≥20 mg/mL
H2O: insoluble
ethanol: soluble
起源
Johnson & Johnson
儲存溫度
room temp
SMILES 字串
Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5
InChI
1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
InChI 密鑰
QOYHHIBFXOOADH-UHFFFAOYSA-N
基因資訊
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
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應用
氟司必林已用于研究其作为神经安定药物对人ether-a-go-go相关基因(HERG)的影响。
氟司必林已用于研究其对恶性神经胶质瘤的细胞毒性作用。
生化／生理作用
氟司必林(Fluspirilene)是一种多巴胺受体拮抗剂。也可充当钙通道阻断剂。氟司必林是一种抗精神病药物，具有精神安定作用。对胶质母细胞瘤和精神分裂症有治疗作用。
氟司必林可抑制周期蛋白依赖性激酶2(CDK2)的活性。可作为抗癌药有效治疗人肝细胞癌。
特點和優勢
该化合物由 Johnson & Johnson 开发。浏览其他由制药公司开发的化合物以及批准药物/候选药物清单， 请单击此处。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
J P Galizzi et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(19), 7513-7517 (1986-10-01)
[3H]Fluspirilene, a neuroleptic molecule of the diphenylbutylpiperidine series, binds to skeletal muscle transverse tubule membranes with a high affinity corresponding to a Kd of 0.11 +/- 0.04 nM, A 1:1 stoichiometry was found between [3H]fluspirilene binding and the binding of
The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug.
P A Janssen et al.
Arzneimittel-Forschung, 20(11), 1689-1698 (1970-11-01)
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug
Dong Y, et al.
Oncotarget, 8(67), 111728-111728 (2017)
Qin Cao et al.
Nature chemistry (2018-10-10)
Inhibiting the interaction between amyloid-β (Aβ) and a neuronal cell surface receptor, LilrB2, has been suggested as a potential route for treating Alzheimer's disease. Supporting this approach, Alzheimer's-like symptoms are reduced in mouse models following genetic depletion of the LilrB2
Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists.
Sah, DW and Bean, Bruce P
Molecular Pharmacology, 45(1), 84-92 (1994)
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