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Merck
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D0400

Sigma-Aldrich

9,11-二甲氧基-9α，11α-环氧甲氧基前列腺素F2α

别名:

U44069

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About This Item

经验公式（希尔记法）:
C21H34O4
CAS号:
56985-32-1
分子量:
350.49
MDL號碼:
MFCD00135237
分類程式碼代碼:
12352211
PubChem物質ID:
24893231
NACRES:
NA.77

描述

solution in methyl acetate

品質等級

200

形狀

liquid

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CCCCC[C@H](O)\C=C\[C@H]1[C@@H]2CO[C@@H](C2)[C@@H]1C\C=C/CCCC(O)=O

InChI

1S/C21H34O4/c1-2-3-6-9-17(22)12-13-18-16-14-20(25-15-16)19(18)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17-,18-,19+,20-/m0/s1

InChI 密鑰

DJKDIKIDYDXHDD-IGUVKOCZSA-N

生化／生理作用

Prostaglandin F2α analogue; thromboxane A2/prostaglandin H2 mimetic.

象形圖

FlameExclamation mark
GHS02,GHS07

訊號詞

Danger

危險聲明

H225,H319,H336

危險分類

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

標靶器官

Central nervous system

安全危害

EUH066

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

8.6 °F

閃點（°C）

-13 °C

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析证书(COA)

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K Hayashi et al.
Journal of the American Society of Nephrology : JASN, 8(1), 25-31 (1997-01-01)
The thromboxane A2 (TXA2) mimetic U44069 has been demonstrated to reduce the GFR and filtration fraction of the normal isolated perfused rat kidney markedly, suggesting a predominant constriction of preglomerular vessels. To assess this possibility directly, effects of U44069 on
G P Dubé et al.
The Journal of pharmacology and experimental therapeutics, 272(2), 799-807 (1995-02-01)
A novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]-bicyclohept-2-e xo- yl]-heptenoic acid [(+)-S-145], was evaluated in guinea pigs to assess the in vivo pharmacodynamic profile of this compound at vascular, cardiac and platelet TXA2/PGH2 receptors. Comparison was made to the
R F Wideman et al.
Poultry science, 78(5), 714-721 (1999-05-06)
Bolus i.v. injections of 1.2 N HCl elicit a rapid but transient pulmonary vasoconstriction in broiler chickens. In mammals, the pulmonary vasoconstrictive response to bolus acid injection depends on increased synthesis of thromboxane A2; however, the vascular responsiveness of domestic
J A Scott et al.
American journal of respiratory and critical care medicine, 154(3 Pt 1), 629-632 (1996-09-01)
Nonadrenergic noncholinergic (NANC) vasodilator mechanisms may contribute to the maintenance of low vascular resistance characteristic of the pulmonary circulation. Previous studies have demonstrated that nitric oxide (NO) is the principal NANC neurotransmitter in guinea pig pulmonary arteries. We examined whether
I Mark Bowen et al.
The Journal of heart valve disease, 13(4), 593-599 (2004-08-18)
The equine aortic valve is subject to non-inflammatory degenerative changes, associated with aortic valvular regurgitation (AR). This disease shares pathological and epidemiological features with AR in humans, and may serve as a useful model to study in-vitro functional responses associated
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