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Merck
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224M-1

Sigma-Aldrich

Beta-Catenin (14) Mouse Monoclonal Antibody

clone 14, unconjugated, Cell Marque™

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

14, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (224M-14)
vial of 0.5 mL concentrate (224M-15)
bottle of 1.0 mL predilute (224M-17)
vial of 1.0 mL concentrate (224M-16)
bottle of 7.0 mL predilute (224M-18)

製造商／商標名

Cell Marque™

濃度

1.0-5.0 μg/mL (predilute)
25-125 μg/mL (concentrate)

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

同型

IgG1

控制

fibromatosis of breast

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

membranous, nuclear

相关类别

一般說明

Beta-Catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. This protein is associated with E-Cadherin and may be essential for the function of E-Cadherin. Mutations in the Beta-Catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis lesions of the breast and abdomen and therefore is useful in differentiating this lesion from other spindle cell lesions that may occur in these locations. Nuclear accumulation of Beta-Catenin has also been demonstrated in colorectal carcinoma.

品質


IVD
IVD
IVD
RUO

聯結

Beta-Catenin Positive Control Slides, Product No. 224S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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C Kuhnen et al.
Pathology, research and practice, 196(5), 299-304 (2000-06-02)
Apart from its role in cell-adhesion, beta-catenin is regarded as an oncoprotein, the cytoplasmic level of which is regulated by APC as a tumor suppressor protein. Changes of chromosome 5q, the region that includes the APC-gene, are known to be
Elizabeth Montgomery et al.
The American journal of surgical pathology, 26(10), 1296-1301 (2002-10-03)
Although separating gastrointestinal stromal tumor (GIST) from mesenteric fibromatosis and sclerosing mesenteritis is clinically important, this distinction sometimes poses problems for practicing pathologists. In the STI571 (Gleevec, Imatinib) era, the problem may be further compounded when protocol-driven staining for CD117
Susan C Abraham et al.
Human pathology, 33(1), 39-46 (2002-02-02)
Fibromatoses of the breast are nonmetastasizing tumors, but can be infiltrative and locally recurrent. Breast fibromatoses are rare, and their specific genetic alterations have not been elucidated. However, their occasional occurrence in patients with familial adenomatous polyposis (FAP) and their
B A Alman et al.
The American journal of pathology, 151(2), 329-334 (1997-08-01)
Sporadic aggressive fibromatosis (also called desmoid tumor) is a monoclonal proliferation of spindle (fibrocyte-like) cells that is locally invasive but does not metastasize. A similarity to abdominal fibromatoses (desmoids) in familial adenomatous polyposis and a cytogenetic study showing partial deletion
Mohiuddin M Taher et al.
Oncology letters, 18(5), 5063-5076 (2019-10-16)
Choroid plexus papilloma (CPP) is a rare benign tumor of the central nervous system that is usually confined to the cerebral ventricles. According to the World Health Organization, CPP corresponds to a grade I atypical CPP (a-CPP); however, it can
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Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

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