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L0745000

洛莫司汀

European Pharmacopoeia (EP) Reference Standard

别名:

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

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About This Item

经验公式（希尔记法）:
C9H16ClN3O2
CAS号:
13010-47-4
分子量:
233.70
MDL號碼:
MFCD00012392
分類程式碼代碼:
41116107
PubChem物質ID:
329817373
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

lomustine

製造商／商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

ClCCN(N=O)C(=O)NC1CCCCC1

InChI

1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

InChI 密鑰

GQYIWUVLTXOXAJ-UHFFFAOYSA-N

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相关类别

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Lomustine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化／生理作用

Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險聲明

H301,H350

危險分類

Acute Tox. 3 Oral - Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析证书(COA)

Lot/Batch Number

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Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques.
L M Fulton et al.
Seminars in veterinary medicine and surgery (small animal), 5(4), 241-245 (1990-11-01)
G A Kaltsas et al.
Clinical endocrinology, 57(2), 169-183 (2002-08-03)
Combination chemotherapy with the two agents streptozotocin (SZT), which is a nitrosurea, and 5-fluorouracil (5-FU), an alkylating agent, has a long-established role in the treatment of neuroendocrine tumours; however, it is often accompanied by considerable toxicity, and it has not
The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.
S J Proctor et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 21(2), 426-428 (2009-11-11)
The nitrosoureas: carmustine (BCNU) and lomustine (CCNU).
R B Weiss et al.
Cancer treatment reviews, 9(4), 313-330 (1982-12-01)

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