86541

丙酸睾酮

tested according to Ph. Eur.

• 别名: 丙酸睾丸素, 17β-Hydroxy-4-androsten-3-one 17-propionate, 17β-Propionyloxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one 17-propionate
• 经验公式（希尔记法）: C₂₂H₃₂O₃
• CAS号: 57-85-2
• 分子量: 344.49
• Beilstein: 3221760
• EC號碼: 200-351-1
• MDL號碼: MFCD00003653
• 分類程式碼代碼: 12352211
• PubChem物質ID: 329769470
• NACRES: NA.21

属性

• agency: USP/NF; tested according to Ph. Eur.
• 形狀: solid
• 藥物控制: USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada
• SMILES 字串: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])OC(=O)CC
• InChI: 1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
• InChI 密鑰: PDMMFKSKQVNJMI-BLQWBTBKSA-N
• 基因資訊: human ... AR(367) , CYP17A1(1586) ; rat ... Ar(24208)

说明

一般說明

Testosterone propionate is the esterified form of testosterone that is most commonly used in clinical applications for the treatment of hypogonadism, oligospermia, and impotence. 17β-hydroxyl group of propionate is esterified to get this form. It is a fast and short-acting form when compared to enanthate and cypionate forms, which are long-acting esters more commonly used in androgen replacement therapies.

應用

Testosterone propionate has been used:

• to determine the effect of testosterone on the uptake of certain amino acids, such as isoleucine and α-(methylamino)isobutyric acid
• in a study to understand the effects of testosterone on brain aromatase activity in neonatal quail brain
• for testosterone treatment of Celf1 knockout mice in a study to investigate the upregulation of aromatase activity in association with hypogonadism
• to investigate the ontogeny of aromatase-expressing neurons in Japanese quail brain
• to study the effects of in vivo administration of testosterone propionate on fluid reabsorption in the efferent ducts of rat.

生化／生理作用

Testosterone is the major circulating androgen in men and is mainly produced by the testis. A small amount is secreted by the adrenal gland. It is produced from cholesterol in the Leydig cells. Testosterone is metabolized to dihydrotestosterone, a potent androgen that associates with a cytoplasmic receptor protein, to form a complex. This complex is activated and transported into the nucleus, where it triggers several biological responses. It mainly participates in the development of the male phenotype during embryogenesis and at puberty.

其他說明

可能实行销售限制

安全信息

• 象形圖: GHS08,GHS07,GHS09
• 訊號詞: Danger
• 危險聲明: H302,H351,H360FD,H400
• 防範說明: P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1A
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges