ABS455

Anti-IL-31 Antibody

from rabbit, purified by affinity chromatography

• 别名: Interleukin 31, IL-31
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, rat
• 物種活性（以同源性預測）: human (immunogen homology)
• 技術: immunohistochemistry: suitable; western blot: suitable
• UniProt登錄號: Q6EAL8
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... IL31(386653)

说明

一般說明

Interleukin-31 (IL-31) is a T-cell cytokine that activates STAT3 and possibly STAT1 and STAT5 through the IL-31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 is similar to IL-6 type cytokines and is produced mainly by T helper type 2 cells. The ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor is the mediator of IL-31 activity. These proteins activate the JAK/STAT and the AKT signaling pathways in response to IL-31 binding. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes and expressed highly in epithelial cells. Overexpression of IL-31 in transgenic mice results in the development of pruritis, alopecia, and skin lesions. Mutations of IL-31 in humans may result in atopic dermatitis, suggesting that IL-31 may play a role in skin immunity and may represent a novel target for antipruritic drug development.

特異性

This antibody recognizes the N-terminus of IL-31.

免疫原

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of human IL-31.

應用

Anti-IL-31 Antibody is a highly specific rabbit polyclonal antibody, that targets IL-31 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected IL-31 in rat skeletal muscle tissue.

Research Category
Signaling

Research Sub Category
Developmental Signaling

品質

Evaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: 2.5 µg/mL of this antibody detected IL-31 in 15 µg of RAW264.7 cell lysate.

標靶描述

~30 kDa observed. Uncharacterized bands may appear in some lysate(s).

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
RAW264.7 cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable