ABN309

Anti-SAPAP1 Antibody

from rabbit, purified by affinity chromatography

• 别名: SAP90, PSD-95-associated protein 1, Disks large-associated protein 1, DLGAP1, DAP-1, GKAP
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 技術: immunohistochemistry: suitable; western blot: suitable
• UniProt登錄號: O14490
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... DLGAP1(9229)

说明

一般說明

PSD-95/SAP90-binding protein 1 (SAPAP1) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP1 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1 mRNA is targeted to cell bodies in a similar manner to SAPAP2 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM).

特異性

At least three isoforms of SAPAP1 are known to exist. This SAPAP1 antibody will not cross-react with other SAPAP proteins.

免疫原

KLH-conjugated linear peptide corresponding to human SAPAP1.

應用

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SAPAP1 in human brain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This SAPAP1 antibody is validated for use in WB & IHC for the detection of the SAPAP1 protein.

品質

Evaluated by Western Blot in human brain tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected SAPAP1 in 10 µg of human brain tissue lysate.

標靶描述

~95 kDa observed. Uniprot describes 7 isoforms ranging between ~70 and ~109 kDa An uncharacterized band may appear at ~58 kDa in some lysates. The calculated molecular weight is 109 kDa, however SAPAP1 has been shown as a ~95 kDa band in western blots. (Naisbitt, S., et al. (1997). 17(15):5687-5696.)

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human brain tissue lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable