ABC438
Anti-PKM2 Antibody
serum, from rabbit
别名:
Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58
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所有图片(2)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
rabbit
品質等級
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
human, rat, mouse
技術
immunohistochemistry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... PKM(5315)
一般說明
Pyruvate kinase isozymes M1/M2 (PKM2) is also called Cytosolic thyroid hormone-binding protein (CTHBP), Opa-interacting protein 3 (OIP-3), Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1 (THBP1) and p58. PKM2 is a glycolytic enzyme that assists in generating ATP. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. This control of glycolysis and is important for tumor cell proliferation and survival. PKM2 is specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, and cancer cells.
特異性
This antibody is specific to PKM2.
免疫原
Linear peptide corresponding to human PKM2.
應用
Anti-PKM2 Antibody detects level of PKM2 & has been published & validated for use in WB and IHC.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected PKM2 in 10 µg of C2C12, HEK293, HeLa, HepG2, human placenta, HUVEC, Jurkat, L6, mouse brain, NIH/3T3, PC12, PC3, and RAW264.7 lysate.
Western Blotting Analysis: A representative lot detected PKM2 in HEK293 cell lysate (Christofk, R. H., et al. (2008). Nature. 452:230-233).
Immunohistochemistry Analysis: A representative lot detected PKM2 in HEK293 tissue (Christofk, R. H., et al. (2008). Nature. 452:230-233).
Western Blotting Analysis: A representative lot detected PKM2 in HEK293 cell lysate (Christofk, R. H., et al. (2008). Nature. 452:230-233).
Immunohistochemistry Analysis: A representative lot detected PKM2 in HEK293 tissue (Christofk, R. H., et al. (2008). Nature. 452:230-233).
品質
Evaluated by Western Blotting in A431 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected PKM2 in 10 µg of A431 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected PKM2 in 10 µg of A431 cell lysate.
標靶描述
~ 58 kDa observed
外觀
Unpurified
Rabbit polyclonal serum with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Heather R Christofk et al.
Nature, 452(7184), 230-233 (2008-03-14)
Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative phosphorylation. This persistence of high lactate production by tumours in the presence of oxygen, known as aerobic glycolysis, was first noted by Otto Warburg more than
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