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Key Documents

264150

Sigma-Aldrich

Caspase-3 Substrate IV, Fluorogenic

Fluorogenic caspase-3 substrate.

别名:

Caspase-3 Substrate IV, Fluorogenic, Z-DEVD-AFC

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About This Item

经验公式(希尔记法):
C36H38F3N5O14
分子量:
821.71
分類程式碼代碼:
12352202
NACRES:
NA.77

品質等級

化驗

≥95% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze

顏色

white to off-white

溶解度

DMSO: 10 mg/mL

螢光

λex ~400 nm
λem ~505 nm

運輸包裝

ambient

儲存溫度

−20°C

一般說明

Fluorogenic CPP-32/apopain substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Excitation max: ~400 nm; emission max: ~505 nm.
Fluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.

生化/生理作用

Cell permeable: no
Primary Target
Fluorogenic caspase-3 substrate.
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Z-Asp-Glu-Val-Asp-AFC

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

其他說明

Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Kluck, R.M., et al. 1997. Science275, 1132.
Talanian, J., et al. 1997. J. Biol. Chem.272, 9677.
Chinnaiyan, A.M., et al. 1996. Curr. Biol.6, 897.
Nicholson, D.W., et al. 1995. Nature376, 37.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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