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Merck
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Key Documents

14-486-M

Sigma-Aldrich

p70 S6 Kinase Protein, active, 10 µg

Active, N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase, for use in Kinase Assays.

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About This Item

分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.41

生物源

human

品質等級

重組細胞

expressed in Sf21 cells

分子量

Mw 48.7 kDa

製造商/商標名

Upstate®

技術

activity assay: suitable (kinase)

UniProt登錄號

基因資訊

human ... RPS6KB1(6198)

一般說明

N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase
Product Source: Expressed in Sf21 cells

生化/生理作用

Protein Target: p70S6K
Target Sub-Family: AGC

包裝

Also available in 250μg size as catalog # 14-486M.

品質

Routinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2

外觀

Ni2+/NTA-agarose

儲存和穩定性

6 months at -70°C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Jason A Lehman et al.
The Journal of biological chemistry, 278(30), 28130-28138 (2003-05-13)
We report here for the first time the detection of the ribosomal p70S6 kinase (p70S6K) in a hematopoietic cell, the neutrophil, and the stimulation of its enzymatic activity by granulocyte macrophage colony-stimulating factor (GM-CSF). GM-CSF modified the Vmax of the

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