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化驗
98%
形狀
solid
mp
108-111 °C (lit.)
溶解度
H2O: very soluble
alcohol: soluble
SMILES 字串
Cl.CN(CCCl)CCCl
InChI
1S/C5H11Cl2N.ClH/c1-8(4-2-6)5-3-7;/h2-5H2,1H3;1H
InChI 密鑰
QZIQJVCYUQZDIR-UHFFFAOYSA-N
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應用
Mechlorethamine hydrochloride was used in a fluorescence-based apurinic/apyrimidinic site cleavage assay for the identification of apurinic/apyrimidinic endonuclease inhibitors in human cells. It was used in a study to demonstrate the effect of povidone iodine ointment against skin toxicity caused by sulphur and nitrogen mustard.
生化／生理作用
Mechlorethamine hydrochloride administration reduces the tensile strength of the abdominal wounds in rats.
訊號詞
Danger
危險分類
Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Carc. 1B - Eye Dam. 1 - Muta. 1B - Repr. 1B - Skin Corr. 1B
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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U Wormser et al.
Archives of toxicology, 71(3), 165-170 (1997-01-01)
Mustard gas (sulphur mustard, SM) is a powerful vesicant employed as a chemical weapon. The present study demonstrates the effect of povidone iodine (PI) ointment against skin toxicity caused by SM. Gross and histopathological examinations showed that application of PI
Srinivasan Madhusudan et al.
Nucleic acids research, 33(15), 4711-4724 (2005-08-23)
The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. The major AP
Effect of mechlorethamine hydrochloride (nitrogen mustard) on healing of abdominal wounds.
S M FARHAT et al.
A.M.A. archives of surgery, 76(5), 749-751 (1958-05-01)
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