POMC
proopiomelanocortin
别名:
ACTH, CLIP, LPH, MSH, NPP, POC
物种:
Human POMC (5443), Mouse Pomc (18976), Rat Pomc (24664), chicken POMC (422011), dog POMC (403659), domestic cat POMC (101087223), Horse POMC (100071524), cow POMC (281416), Goat POMC (100861398), sheep POMC (443212) ...展开
UniProtKB ID:
基因ID:
- Human(5443) Summary: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
- Mouse(18976) pro-opiomelanocortin-alpha
- Rat(24664) proopiomelanocortin
- chicken(422011) proopiomelanocortin
- dog(403659) proopiomelanocortin
- domestic cat(101087223) proopiomelanocortin
- Horse(100071524) proopiomelanocortin
- cow(281416) proopiomelanocortin
- Goat(100861398) proopiomelanocortin
- sheep(443212) proopiomelanocortin
- naked mole-rat(101718053) proopiomelanocortin
- domestic guinea pig(100720803) proopiomelanocortin
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Antibodies
货号
说明
物种反应性
应用
Anti-Proopiomelanocortin/POMC antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-POMC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry
Anti-POMC Antibody, clone 2J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse, rat
应用
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot