BCR
breakpoint cluster region
别名:
ALL, BCR1, CML, D22S11, D22S662, PHL
物种:
Human BCR (613), Mouse Bcr (110279), Rat Bcr (309696), Zebrafish bcr (568320), domestic cat BCR (101101671), cow BCR (789892), dog BCR (607482), chicken BCR (416952), Domestic Rabbit BCR (100339436), naked mole-rat Bcr (101716702)
UniProtKB ID:
基因ID:
- Human(613) Summary: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(110279) breakpoint cluster region
- Rat(309696) breakpoint cluster region
- Zebrafish(568320) breakpoint cluster region
- domestic cat(101101671) breakpoint cluster region
- cow(789892) breakpoint cluster region
- dog(607482) breakpoint cluster region
- chicken(416952) breakpoint cluster region
- Domestic Rabbit(100339436) breakpoint cluster region
- naked mole-rat(101716702) breakpoint cluster region
- domestic guinea pig(100718992) breakpoint cluster region
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Antibodies
货号
说明
物种反应性
应用
Anti-BCR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-phospho-Bcr (pTyr360) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
western blot
Anti-BCR (N-term) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution,
物种反应性
human
应用
ELISA
Anti-BCR antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
ELISA
immunohistochemistry
immunohistochemistry
Anti-phospho-BCR (pTyr177) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
immunohistochemistry
western blot
western blot
Cell Lines
货号
说明
物种
Proteins
货号
说明
物种
BCR (1-695), GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human