- Recycled IL-7 Can Be Delivered to Neighboring T Cells.
Recycled IL-7 Can Be Delivered to Neighboring T Cells.
Journal of immunology (Baltimore, Md. : 1950) (2015-04-15)
Douglas A Bazdar, Magdalena Kalinowska, Soumya Panigrahi, Scott F Sieg
PMID25870237
ABSTRACT
IL-7 is a key homeostatic cytokine that provides signals for T cell survival and proliferation in vivo. In this article, we provide evidence that IL-7 utilization is enhanced by a novel mechanism of cytokine "recycling" during which T cells treated with rIL-7 are rapidly induced to express p-STAT5 and are subsequently able to recycle biologically active cytokine for release to neighboring cells in soluble form. Our observations indicate that the ability of cells to recycle IL-7 is dependent on IL-7R α-chain (CD127) and endocytosis, consistent with a model whereby IL-7 is internalized via receptor interactions before recycling. These observations provide evidence of a novel mechanism that enables cells to optimally use IL-7.
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Formaldehyde solution, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
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