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  • The effect of intraarticular levobupivacaine and bupivacaine injection on the postoperative pain management in total knee artroplastic surgery.

The effect of intraarticular levobupivacaine and bupivacaine injection on the postoperative pain management in total knee artroplastic surgery.

Pakistan journal of medical sciences (2015-02-13)
Nurcan Yavuz, Vildan Taspinar, Derya Karasu, Aysu Tezcan, Bayazit Dikmen, Nermin Gogus
ABSTRACT

Total knee arthroplasty (TKA) is associated with considerable postoperative pain. We compared the effects of intraoperative intraarticular levobupivacaine and bupivacaine on postoperative analgesia and analgesic consumption after total knee arthroplasty. Sixty ASA (American Society of Anesthesiologists) physical status II-III, 18-75 years old patients scheduled for unilateral TKA were included in this study. For the operative procedure combined spinal epidural anesthesia was given by injecting 15mg levobupivacaine in subarachnoid space at L3-4/L4- 5 in sitting position for all patients. In Group L 20ml levobupivacaine(0.5%), in Group B 20ml bupivacaine (0.5%) was injected intraarticularly 10 minutes before opening of the tourniquet at the end of the surgery. For all patients postoperative analgesia was provided with PCEA (levobupivacaine+fentanyl) and oral 1gr paracetamol four times a day. Patients' intraoperative-postoperative hemodynamical data, postoperative sensorial-motor block characteristics, side effects, PCEA demand ratios and bolus volumes, total analgesic consumption, VAS values, first mobilization time, hospitalization time were recorded. Statistical analysis was performed with SPSS version 13.00 software. There was no intergroup difference in demographic data, hemodynamical data, PCEA demand ratios, total analgesic consumption, first mobilization time, hospitalization time and VAS values at 0,2,72 hour. Postoperative lower VAS values were determined at 4,8,12,24 hours in Group B and at 48(th) hour in Group L(p<0.05). Intraarticular local anesthetic administration in addition to PCEA for post operative pain relief provides good analgesia after TKA surgery.

MATERIALS
Product Number
Brand
Product Description

Supelco
Bupivacaine hydrochloride monohydrate, analytical standard, for drug analysis
Supelco
Perchloric acid concentrate, 0.01 M HClO4 in water (0.01N), eluent concentrate for IC
Sigma-Aldrich
Perchloric acid, ACS reagent, 60%
Sigma-Aldrich
Perchloric acid, puriss. p.a., ACS reagent, packed in coated, shock- and leak-protected glass bottle, ≥60% (T)
Sigma-Aldrich
Perchloric acid, 70%, 99.999% trace metals basis
Sigma-Aldrich
Perchloric acid, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 70.0-72.0%
Sigma-Aldrich
Perchloric acid, ACS reagent, 70%
Sigma-Aldrich
Perchloric acid, SAJ super special grade, 60.0-62.0%
Sigma-Aldrich
Perchloric acid, 0.1 M
Supelco
Bupivacaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
USP
Bupivacaine hydrochloride, United States Pharmacopeia (USP) Reference Standard
Bupivacaine hydrochloride, European Pharmacopoeia (EP) Reference Standard