Skip to Content
Merck
  • Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Pharmaceutical development and technology (2013-11-14)
Srinivasa M Sammeta, Li Wang, Shravan K Mutyam, Kathleen O'Loughlin, Carol E Green, Milton H Werner, Terence Kelly, Gita N Shankar
ABSTRACT

The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were subjected to in vitro intestinal drug permeability studies conducted with Ussing chambers. Vitamin E tocopherol polyethylene glycol succinate and propylene glycol based co-solvent formulations provided the maximum permeability coefficient for the drug. Inclusion complexes of the drug were prepared using hydroxypropyl-β-cyclodextrin and sulphobutylether cyclodextrins. Pharmacokinetic studies were carried out in male Sprague-Dawley rats for the selected formulations. The relative bioavailabilities of the drug with the co-solvent- and cyclodextrin-based formulations were found to be similar.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Boric acid, SAJ first grade, ≥99.5%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1,2-Propanediol, SAJ first grade, ≥99.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1,2-Propanediol, SAJ special grade, ≥99.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Boric acid, 99.999% trace metals basis
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Boric acid, 99.97% trace metals basis
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1,2-Propanediol, ACS reagent, ≥99.5%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium hydroxide-16O solution, 20 wt. % in H216O, 99.9 atom % 16O
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium phosphate dibasic, BioUltra, for molecular biology, ≥99.5% (T)
SKU
Pack Size
Availability
Price
Quantity
Supelco
Benalaxyl-M, PESTANAL®, analytical standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1,2-Propanediol, ReagentPlus®, 99%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
α-Tocopherol, ≥95.5%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium phosphate dibasic, 99.95% trace metals basis
SKU
Pack Size
Availability
Price
Quantity
α-Tocopherol, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1,2-Propanediol, puriss. p.a., ACS reagent, ≥99.5% (GC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1,2-Propanediol, tested according to Ph. Eur.
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium phosphate dibasic, purum p.a., anhydrous, ≥98.0% (T)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1,2-Propanediol, meets analytical specification of Ph. Eur., BP, USP, ≥99.5%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Boric acid, BioUltra, for molecular biology, ≥99.5% (T)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Boric acid, BioReagent, for molecular biology, suitable for cell culture, suitable for plant cell culture, ≥99.5%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium phosphate dibasic, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium phosphate dibasic, ReagentPlus®, ≥99.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium phosphate dibasic, BioXtra, ≥99.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
(+)-α-Tocopherol, Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
(+)-α-Tocopherol, from vegetable oil, Type V, ~1000 IU/g
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sodium phosphate dibasic, for molecular biology, ≥98.5% (titration)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Boric acid, suitable for electrophoresis, ≥99.5%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Boric acid, BioXtra, ≥99.5%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Boric acid, tablet, 1 g boric acid per tablet
SKU
Pack Size
Availability
Price
Quantity
Supelco
Noscapine hydrochloride hydrate, analytical standard
SKU
Pack Size
Availability
Price
Quantity
Supelco
1,2-Propanediol, analytical standard
SKU
Pack Size
Availability
Price
Quantity