Ion Exchange Chromatography Resins
Ion exchange (IEX) chromatography is a commonly used purification method that separates a target molecule from other impurities based on the net surface charge. Our portfolio of anion exchange (AEX) and cation exchange (CEX) resins, with our multi-modal chromatography resins, offers efficient purification solutions for mAbs, vaccines, plasmid DNA, plasma, and other modalities.
Eshmuno® IEX chromatography resins
These resins are ideal for efficient downstream purification and contain our proven tentacle ligand technology coupled with rigid base beads. They operate at fast flowrates and maintain high binding capacities, improving productivity by reducing time and manufacturing costs.
Eshmuno® CMX mixed-mode resin provides high selectivity for mAbs, fusion proteins, and ADC purification, as well as separation of low molecular weight impurities and HCPs.
Eshmuno® CP-FT resin efficiently removes mAb aggregates in flow-through mode, resulting in 10 times higher loading capacities as compared to traditional bind/elute CEX chromatography. This enables process intensification while reducing the overall cost for downstream mAb purification.
Eshmuno® CPS resin offers high dynamic binding capacity and separation efficiency of recombinant protein feed streams at elevated salt concentrations. This enables direct loading of high-conductivity feed streams (conductivity ≥10 mS/cm), reducing the need for dilution.
Eshmuno® CPX resin separates mAb monomers from aggregates and other impurities, even at high loading. It delivers outstanding productivity for high-resolution purification of process intermediates.
Eshmuno® HCX resin provides fast, efficient, direct capture of proteins, delivering outstanding performance in typical ion exchange and flow-through applications at higher salt levels.
Eshmuno® S is a strong CEX resin for direct capture of recombinant proteins and fast, efficient mAb purification following protein A capture.
Eshmuno® Q is a strong anion resin, offering outstanding impurity removal in typical anion exchange flow-through applications.
Fractogel® EMD IEX chromatography resins
All Fractogel® EMD resins provide high selectivity coupled with consistent pressure stability, enabling very high throughput and excellent yields. The resin’s high binding capacity, even at high flow rates, saves valuable time and improves process economics. Fractogel® resins are offered in different bead sizes with multiple functional groups to meet a range of purification needs:
Fractogel® strong anion exchangers
- Fractogel® EMD TMAE (S) Resin
- Fractogel® EMD TMAE (M) Resin
- Fractogel® EMD TMAE Hicap (M) Resin
- Fractogel® EMD TMAE Medcap (M) Resin
Fractogel® weak anion exchangers
Fractogel® strong cation exchangers
Fractogel® weak cation exchangers
Support for qualification, risk assessment, and process optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Product Selection Guides
Biochromatography Portfolio
Chromatography Purification Selection
Product Data Sheets
Eshmuno® CMX Resin
Eshmuno® CP‑FT Resin
Eshmuno® CPS
Eshmuno® CPX
Eshmuno® HCX Media
Eshmuno® S Resin for Superior Downstream mAB Purification
Eshmuno® Q Resin for Efficient AEX Chromatography
Fractogel® Chromatography Resin
Robocolumn® and Minichrom Chromatography Columns
Related Resources
Animation: Separation of Low or Too High DAR Antibody Drug Conjugate Species
mAbsizer™ Calculator
Related Articles
Cation Exchange Frontal Chromatography for the Removal of Monoclonal Antibody Aggregates
Viral Clearance in Antibody Purification Using Tentacle Ion Exchangers
Bioprocessing Technology Trends of RNA-based Therapeutics and Vaccines
RNA-Based Therapeutics and Vaccines
Design Space and Robustness Analysis of Batch and Counter-current Frontal Chromatography Processes for the Removal of Antibody Aggregates
Process Intensification by Frontal Chromatography
Application Notes
ADC Separation Using a Mixed Mode Cation Exchange Chromatography Step in a mAb Process
Intensified Polishing Using Single-pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
Eshmuno® CMX Application Note on Glycovariant Separation Including for COVID-19
Development Strategy for a Cation Exchange (CEX) Chromatography Step in a Monoclonal Antibody (mAb) Process
New technologies enabling efficient DAR species separation with the possibility to reduce manufacturing costs & simplify process optimization
CEX flow-through frontal chromatography for the removal of mAb aggregates as well as the conditions that influence the removal of these aggregates
Video: Vaccine tentacle technology
Eshmuno® CMX mixed-mode chromatography resin for the purification of vaccines
Video: Explore Efficiency: Eshmuno® CP‑FT Resin
Explore the significant cost savings in mAb downstream purification by utilizing Eshmuno® CP-FT Resin
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