R8526
RO-52 (SSA) human
recombinant, expressed in E. coli, liquid
Synonym(s):
Anti-RO-52 antibody
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
form
liquid
mol wt
52 kDa by SDS-PAGE
technique(s)
ELISA: suitable
UniProt accession no.
storage temp.
−70°C
Gene Information
human ... TRIM21(6737)
General description
Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
Application
RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
Biochem/physiol Actions
RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
Physical form
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Anti-ro52 antibodies and interstitial lung disease in connective tissue diseases excluding scleroderma
Ferreira J, et al.
ISRN rheumatology, 2012, 415-421 (2012)
Autoantigen TRIM21/Ro52 as a possible target for treatment of systemic lupus erythematosus
Yoshimi R, et al.
International journal of rheumatology, 2012, 6277-6285 (2012)
Electronic Structure Calculation and Superconductivity in lambda-(BETS) 2GaCl4
Aizawa H, et al.
Journal of the Physical Society of Japan, 87(9), 093701-093701 (2018)
Serological epitope profile of anti-Ro52-positive patients with systemic autoimmune rheumatic diseases
Infantino M, et al.
Arthritis Research & Therapy, 17(1), 365-365 (2015)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service