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Merck

DDC

dopa decarboxylase (aromatic L-amino acid decarboxylase)

Synonyms:
AADC
Species:
UniProtKB ID:
Gene ID:
  • Human(1644) Summary: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
  • Mouse(13195) dopa decarboxylase
  • Rat(24311) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • domestic guinea pig(100135516) dopa decarboxylase
  • naked mole-rat(101697555) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • sheep(101106765) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • Zebrafish(406651) dopa decarboxylase
  • chicken(420947) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • fruit fly(35190) Dopa decarboxylase
  • dog(606852) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • cow(280762) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • Horse(100052557) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • domestic cat(101082989) dopa decarboxylase (aromatic L-amino acid decarboxylase)

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ELISA

Product Number
Description
Species
Human Dopa Decarboxylase ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-DDC antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-DDC antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL2962, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-DDC antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
guinea pig, human, mouse, rat
Application
western blot
Anti-Dopa Decarboxylase Antibody, Chemicon®, from rabbit,
Species Reactivity
canine, human, sheep
Application
western blot
Anti-DDC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
S-(−)-Carbidopa, ≥98% (TLC), powder,
Species
human
Carbidopa, European Pharmacopoeia (EP) Reference Standard,
Species
human
Carbidopa, United States Pharmacopeia (USP) Reference Standard,
Species
human
Carbidopa, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Carbidopa for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ddc,
Species
mouse