- The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nature communications (2017-01-10)
Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido-Nakahara, Ikuya Tsuge, Masutaka Furue, Yoshinori Fukui
PMID28067314
ABSTRACT
Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4