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USP

Azaerythromycin A

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

9-Deoxo-9a-aza-9a-homoerythromycin A

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About This Item

Empirical Formula (Hill Notation):
C37H70N2O12
CAS Number:
76801-85-9
Molecular Weight:
734.96
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

azithromycin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C37H70N2O12/c1-14-26-37(10,45)30(41)23(6)38-18-19(2)16-35(8,44)32(51-34-28(40)25(39(11)12)15-20(3)47-34)21(4)29(22(5)33(43)49-26)50-27-17-36(9,46-13)31(42)24(7)48-27/h19-32,34,38,40-42,44-45H,14-18H2,1-13H3/t19-,20-,21+,22-,23-,24+,25+,26-,27+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

HRKNNHYKWGYTEN-HOQMJRDDSA-N

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General description

Azaerythromycin is a cladinose containing macrolide antibiotic which is a 15-member ring.

Application

Azaerythromycin A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Azithromycin
  • Azithromycin Capsules
  • Azithromycin for Injection

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Azithromycin dihydrate ≥98% (HPLC)

Sigma-Aldrich

PZ0007

Azithromycin dihydrate

Alaa Khedr et al.
Journal of chromatographic science, 41(1), 10-16 (2003-02-25)
A validated stability-indicating thin-layer chromatographic (TLC) method of the analysis of azithromycin (AZT) in bulk and capsule forms is developed. Both AZT potential impurity and degradation products can be selectively and accurately estimated in both raw material and product onto
Vladimir Vimberg et al.
Molecular microbiology, 54(2), 376-385 (2004-10-08)
Expression of specific short peptides can render cells resistant to macrolide antibiotics. Peptides conferring resistance to structurally different macrolides including oleandomycin, azithromycin, azaerythromycin, josamycin and a ketolide cethromycin were selected from a random pentapeptide expression library. Analysis of the entire
S Djokić et al.
The Journal of antibiotics, 40(7), 1006-1015 (1987-07-01)
Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A (5), the new 15-membered semi-synthetic macrolide antibiotic with nitrogen as additional atom in the aglycone ring of erythromycin A (1), was reported. Although amine (5) and its 13,14-cyclic carbonate (14) were less active

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