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M3781

Sigma-Aldrich

6α-Methylprednisolone 21-hemisuccinate sodium salt

lyophilized powder

Synonym(s):

6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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About This Item

Linear Formula:
C26H33O8Na
CAS Number:
2375-03-3
Molecular Weight:
496.53
EC Number:
219-156-8
MDL number:
MFCD00152612
UNSPSC Code:
51111800
PubChem Substance ID:
24896873
NACRES:
NA.77

biological source

synthetic

sterility

non-sterile

Assay

≥98.00% (TLC)

form

lyophilized powder

technique(s)

toxicology assay: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

Gene Information

human ... NR3C1(2908)

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Application

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Physical form

Lyophilized containing ~5% phosphate buffer salts.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Matthias D'Hondt et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 69(3), 232-240 (2012-01-21)
The short-term stability of extemporaneously prepared triple intrathecal therapy, containing cytarabine, methotrexate sodium, and methylprednisolone sodium succinate, was evaluated. Three batches of triple intrathecal solution were prepared using commercially available products and stored in three different packaging materials (plastic syringe
Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells
Zou W, et al.
Journal of Bone and Mineral Metabolism, 33(6), 615-624 (2015)
Basilar leptomeningitis in Vogt-Koyanagi-Harada disease.
Yince Loh
Neurology, 78(6), 438-439 (2012-02-09)
Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy.
Sabrina Fourcade et al.
Archives of dermatology, 147(10), 1227-1228 (2011-10-19)
Acute liver failure and aplastic anemia in an 11-year-old girl.
Ann Ming Yeh et al.
Digestive diseases and sciences, 56(8), 2237-2240 (2011-03-29)
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