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MPC4NTR10

Millipore

Multiscreen® 96 well Plate, polycarbonate membrane

pore size 0.4 μm, non-sterile

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About This Item

UNSPSC Code:
41104923
eCl@ss:
32039006
NACRES:
NB.22

material

flat bottom wells
polycarbonate membrane
polystyrene

Quality Level

400

description

This 96-well filter plate has a Polycarbonate membrane used for Permeability studies.

sterility

non-sterile

product line

MultiScreen®

feature

lid

manufacturer/tradename

MultiScreen®

parameter

100 μL sample volume (per well)

technique(s)

DNA purification: suitable
activity assay: suitable (with precipitations)
ligand binding assay: suitable
parallel artificial membrane permeation assay (PAMPA): suitable
receptor binding assay: suitable

plate size

96 wells

well maximum volume

300 μL

working volume

125 μL

pore size

0.4 μm pore size

application(s)

sample preparation

shipped in

ambient

Related Categories

General description

Filter Code: PCF
Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput

Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1

PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3

MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.

Application

Research Category
Assays

Protein

Physical form

Color Code: Clear

Other Notes

Automation Compatible: No

Legal Information

MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany

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Articles

Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA)

This is a white paper on the Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA) using MultiScreen® Filter Plates.

Membrane Integrity test for Lipid-PAMPA Artificial Membranes

This is a protocol for a Membrane Integrity test for Lipid-PAMPA Artificial Membranes

Combining Permeability and Solubility Analyses in a Single Workflow

This article details the benefits of combining solubility and a non-cell based permeability assay (Parallel Artificial Membrane Permeation Assay; PAMPA) into a single workflow in which a portion of the filtrate from the MultiScreen® Solubility filter plate is added to the donor compartment of the MultiScreen filter plate for the PAMPA analysis.

Protocols

HDM-PAMPA with the MultiScreen Permeability Filter Plate

HDM-PAMPA with the MultiScreen Permeability Filter Plate

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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