249262

(−)-Corey lactone, 4-phenylbenzoate alcohol

99%

• Synonym(s): (3aα,4α,5β,6aα)-(−)-Hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-yl 1,1′-biphenyl-4-carboxylate, (3aR,4S,5R,6aS)-Hexahydro-4-hydroxymethyl-5-(4-phenylbenzoyloxy)cyclopenta[b]furan-2-one
• Empirical Formula (Hill Notation): C₂₁H₂₀O₅
• CAS Number: 31752-99-5
• Molecular Weight: 352.38
• Beilstein: 1294692
• MDL number: MFCD00078077
• UNSPSC Code: 12352005
• PubChem Substance ID: 24854983
• NACRES: NA.22

Properties

• Assay: 99%
• form: solid
• optical activity: [α]20/D −87°, c = 1 in chloroform
• mp: 131-132 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: OC[C@H]1[C@@H](C[C@@H]2OC(=O)C[C@H]12)OC(=O)c3ccc(cc3)-c4ccccc4
• InChI: 1S/C21H20O5/c22-12-17-16-10-20(23)25-18(16)11-19(17)26-21(24)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-9,16-19,22H,10-12H2/t16-,17-,18+,19-/m1/s1
• InChI key: SZJVIFMPKWMGSX-AKHDSKFASA-N

Description

General description

(−)-Corey lactone, 4-phenyl benzoate alcohol, also known as 2H-cyclopenta[b]furan, [1,1′-biphenyl]-4-carboxylic acid derivative, is commonly used as a chiral substrate and is a versatile building block for prostaglandins.

Application

(−)-Corey lactone, 4-phenyl benzoate alcohol is used as:

• A substrate in the synthesis of tricyclic cyclopent[b]benzofuran.
• A Key intermediate in the synthesis of prostaglandins.
• Building block for a potent and selective antiglaucoma agent analog of PGF_2α

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves