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226017

Sigma-Aldrich

1,2-Naphthoquinone-4-sulfonic acid sodium salt

97%

Synonym(s):

3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt, Folin’s reagent, Sodium 1,2-naphthoquinone-4-sulfonate

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About This Item

Empirical Formula (Hill Notation):
C10H5NaO5S
CAS Number:
521-24-4
Molecular Weight:
260.20
Beilstein:
4169788
EC Number:
208-308-9
MDL number:
MFCD00001700
UNSPSC Code:
12352100
PubChem Substance ID:
24853538
NACRES:
NA.22

Assay

97%

form

powder

mp

289 °C (dec.) (lit.)

solubility

alcohol: slightly soluble 95%
acetone: moderately soluble(lit.)
benzene: insoluble(lit.)
carbon disulfide: insoluble(lit.)
chloroform: insoluble(lit.)
diethyl ether: insoluble(lit.)
petroleum ether: insoluble(lit.)
water: soluble(lit.)

SMILES string

[Na+].[O-]S(=O)(=O)C1=CC(=O)C(=O)c2ccccc12

InChI

1S/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1

InChI key

UBLXEEBHYISRFM-UHFFFAOYSA-M

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Application

1,2-Naphthoquinone-4-sulfonic acid sodium salt (Folin′s reagent) was used in the colorimetric assay for determination of procaine hydrochloride in pharmaceutical preparations.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R B Salama et al.
Journal of pharmaceutical sciences, 69(3), 346-348 (1980-03-01)
A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react
Santiago Hernández-Cassou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(17-18), 1270-1281 (2010-12-28)
This paper revises the derivatization approaches for the determination of biogenic amines in wines. Since most of these amines display poor spectroscopic features to be detected by UV absorption or emission (fluorescence) spectroscopy, derivatization is necessary to attain the desired
Sameer A M Abdulrahman et al.
Drug testing and analysis, 3(10), 748-754 (2011-02-22)
A simple, sensitive, and selective spectrophotometric method has been developed for the determination of gabapentin (GBP) in capsules. The method is based on the reaction of GBP and sodium 1,2-naphthoquinone-4-sulfonate (NQS) in the presence of Clark and Lubs buffer of
Huai You Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(12), 2933-2939 (2004-09-08)
Spectrophotometric determination of dapsone is described. The dapsone reacts with sodium 1,2-naphthoquinone-4-sulfonic in pH 6.98 buffer solution to form a salmon pink compound, and its maximum absorption wavelength is at 525 nm, epsilon525=3.68 x 10(4) l mol(-1) cm(-1). The absorbance
Lixiao Xu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(13), 3007-3012 (2004-10-13)
Spectrophotometric determination of ampicillin sodium is described. The ampicillin sodium reacts with sodium 1,2-naphthoquinone-4-sulfonic in pH 9.00 buffer solution to form a salmon pink compound, and its maximum absorption wavelength is at 463 nm, epsilon463 = 1.14 x 10(4). The
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