Custom qPCR Probes

Dual-Labeled Probes in Digital PCR

Two commonly used quenchers, TAMRA™ and DABYCL, limit the ultimate sensitivity and flexibility of qPCR. TAMRA is not a dark quencher and therefore contributes to an overall increase in background because of its own native fluorescence. DABCYL, though a dark quencher, has an inadequate absorption footprint that overlaps very poorly with reporter dyes emitting above 480 nm.

Molecular Beacons are structured probes that are highly sensitive, sequence specific, and are used for sequence detection in qPCR and in vitro studies.

Dual-Labeled Probes are the most common probe type for qPCR and are often referred to as hydrolysis probes.

Onxy Quencher emits heat instead of light and offers and improved signal-to-noise ratio over fluorescent quenchers.

Label licenses for our oligonucleotide products, including Black Hole Quencher®, BlackBerry® Quencher, and Locked Nucleic Acid (LNA®).

Custom oligo Blanket Purchase Order tracking system simplifies expenditure management for customers.

Key components of our QMS (quality management system) include: certificates of analysis; document control; change notification; vendor management; business agreements; and, corrective and preventive actions.