TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
Synonyms:
APO2L, Apo-2L, CD253, TL2, TRAIL
Species:
Human TNFSF10 (8743), Mouse Tnfsf10 (22035), Rat Tnfsf10 (246775), Zebrafish tnfsf10 (436866), domestic cat TNFSF10 (100174789), domestic cat TNFSF10 (101083289), dog TNFSF10 (100174780), chicken TNFSF10 (378894), cow TNFSF10 (507215), sheep TNFSF10 (101114153) ...More
UniProtKB ID:
Gene ID:
- Human(8743) Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Mouse(22035) tumor necrosis factor (ligand) superfamily, member 10
- Rat(246775) tumor necrosis factor (ligand) superfamily, member 10
- Zebrafish(436866) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(100174789) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(101083289) tumor necrosis factor (ligand) superfamily, member 10
- dog(100174780) tumor necrosis factor (ligand) superfamily, member 10
- chicken(378894) tumor necrosis factor (ligand) superfamily, member 10
- cow(507215) tumor necrosis factor (ligand) superfamily, member 10
- sheep(101114153) tumor necrosis factor (ligand) superfamily, member 10
- domestic guinea pig(100734497) tumor necrosis factor (ligand) superfamily, member 10
- naked mole-rat(101702439) tumor necrosis factor (ligand) superfamily, member 10
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ELISA
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TNFSF10 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-Trail antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-sTRAIL Antibody, clone III6F, clone III6F, from mouse,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
immunohistochemistry
immunoprecipitation (IP)
Monoclonal Anti-CD253 antibody produced in mouse, clone 2E5,
Species Reactivity
human
Application
flow cytometry
Anti-TRAIL/CD253 Antibody, clone 6D12.2, clone 6D12.2, from mouse,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry
immunohistochemistry
Proteins
Product Number
Description
Species
TRAIL human, recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder,
Species
human
TRAIL human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder,
Species
human
TRAIL from mouse, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
mouse
TRAIL Protein, Recombinant human, Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.,
Species
human
TRAIL, Soluble mouse, recombinant, expressed in E. coli, His tagged, >95% (SDS-PAGE),
Species
mouse