- Total synthesis of ecteinascidin 743.
Total synthesis of ecteinascidin 743.
Journal of the American Chemical Society (2006-01-05)
Jinchun Chen, Xiaochuan Chen, Michèle Bois-Choussy, Jieping Zhu
PMID16390134
RÉSUMÉ
A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.
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