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  • Effect of chromatographic conditions on liquid chromatographic chiral separation of terbutaline and salbutamol on Chirobiotic V column.

Effect of chromatographic conditions on liquid chromatographic chiral separation of terbutaline and salbutamol on Chirobiotic V column.

Journal of chromatography. A (2011-08-23)
Hisham Hashem, Clemens Tründelberg, Omer Attef, Thomas Jira
RÉSUMÉ

In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the best separation. The salt concentration in the mobile phase and pH value were found to be the most important chromatographic factors affecting separation. Separation of enantiomers of these two basic analytes was complete in less than 10 min without applying ammonium trifluoroacetate (ATFA) or triethylamine (TEA) salts.

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Supelco
Colonne chirale pour CLHP Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Colonne chirale pour CLHP Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Colonne chirale pour CLHP Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
Colonne chirale pour CLHP Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
Colonne chirale pour CLHP Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
Supelco
Colonne chirale pour CLHP Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 25 cm × 2.1 mm