- Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).
Bioorganic & medicinal chemistry letters (2014-06-03)
Steven M Sparks, Grace Chen, Jon L Collins, Dana Danger, Steven T Dock, Channa Jayawickreme, Stephen Jenkinson, Christopher Laudeman, M Anthony Leesnitzer, Xi Liang, Patrick Maloney, David C McCoy, David Moncol, Vincent Rash, Thomas Rimele, Padmaja Vulimiri, James M Way, Sean Ross
PMID24881566
RÉSUMÉ
The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein.
MATÉRIAUX