- 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.
Bioorganic & medicinal chemistry letters (2005-06-14)
Raman K Bakshi, Qingmei Hong, J T Olson, Zhixiong Ye, Iyassue K Sebhat, David H Weinberg, Tanya MacNeil, Rubana N Kalyani, Rui Tang, William J Martin, Alison Strack, Erin McGowan, Constantin Tamvakopoulos, Randy R Miller, Ralph A Stearns, Wei Tang, D Euan Maclntyre, Lex H T van der Ploeg, Arthur A Patchett, Ravi P Nargund
PMID15951175
RÉSUMÉ
The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.