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Hg(II)-mediated intramolecular cyclization reaction in aqueous media and its application as Hg(II) selective indicator.

Organic letters (2013-02-21)
Ananta Kumar Atta, Seul-Bi Kim, Jungseok Heo, Dong-Gyu Cho
RÉSUMÉ

The Hg(II)-specific intramolecular cyclization reaction of ethynyl phenols was carried out for the first time in semiaqueous media at ambient temperature. The reaction unit (ethynyl phenol) was coupled with a malononitrile derivative (signal unit), which afforded the chromogenic Hg(II) indicator 7. The reaction of the chromogenic Hg(II) indicator 7 was further optimized in DMSO/water (3:7, v/v) (10 mM PBS buffer, pH = 7.0). Compound 7 displays a color change from blue to pale yellow in the presence of Hg(II).

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Sigma-Aldrich
Malononitrile, ≥99%
Sigma-Aldrich
Malononitrile, Arxada quality, ≥99.0% (calculated, GC, KF)